His short poem, which we reproduce as
it first appeared in print, eloquently expresses medieval mans repugnance for
the toad, and reveals how intimate Ripley and his circle must have been with
the toads milky exudate and its fearsome virtue.
Our quotations concerning the toad go back to the Middle Ages and the
Renaissance, but the ideas therein expressed lived on until recent times.
To this humble group rightly belongs
the common field mushroom, a poor thing owing its undeserved renown to
a weakness in its character that makes it unique - it alone in the mushroom
world of Europe and America stoops to mans will by lending itself to
commercial cultivation in a big way. LSD-25 Synthesis from "Psychedelic Guide to the Preparation of the Eucharist":
Starting material may be any lysergic acid derivative, from ergot on rye grain or from culture, or
morning glory seeds or from synthetic sources. Preparation #1 uses any amide, or lysergic acid as
starting material. Preparations #2 and #3 must start with lysergic acid only, prepared from the amides as
10 g of any lysergic acid amide from various natural sources dissolved in 200 ml of methanoic
KOH solution and the methanol removed immediately in vacuo. The residue is treated with 200 ml of an
8% aqueous solution of KOH and the mixture heated on a steam bath for one hour. A stream of
nitrogen gas is passed through the flask during heating and the evolved NH3 gas may be titrated is HCl
to follow the reaction. The alkaline solution is made neutral to congo red with tartaric acid, filtered,
cleaned by extraction with ether, the aqueous solution filtered and evaporated. Digest with MeOH to
remove some of the coloured material from the crystals of lysergic acid.
Arrange the lighting in the lab similarly to that of a dark room. Use photographic red and yellow
safety lights, as lysergic acid derivatives are decomposed when light is present. Rubber gloves must be
worn due to the highly poisonous nature of ergot alkaloids. A hair drier, or, better, a flash evaporator, is
necessary to speed up steps where evaporation is necessary.
Step I. Use Yellow light
Place one volume of powdered ergot alkaloid material in a tiny round bottom flask and add two
volumes of anhydrous hydrazine. An alternate procedure uses a sealed tube in which the reagents are
heated at 112 C. The mixture is refluxed (or heated) for 30 minutes. Add 1.5 volumes of H2O and boil
15 minutes. On cooling in the refrigerator, isolysergic acid hydrazide is crystallised.
Step II. Use Red light
Chill all reagents and have ice handy. Dissolve 2.82 g hydrazine rapidly in 100 ml 0.1 N
ice-cold HCl using an ice bath to keep the reaction vessel at 0 C. 100 ml ice-cold 0.1 N NaNO2 is
added and after 2 to 3 minutes vigorous stirring, 130 ml more HCl is added drop wise with vigorous
stirring again in an ice bath. After 5 minutes, neutralise the solution with NaHCO3 saturated sol. and
extract with ether. Remove the aqueous solution and try to dissolve the gummy substance in ether.
Adjust the ether solution by adding 3 g diethylamide per 300 ml ether extract. Allow to stand in the
dark, gradually warming up to 20 C over a period of 24 hours. Evaporate in vacuum and treat as
indicated in the purification section for conversion of iso-lysergic amides to lysergic acid amides.
Step I. Use Yellow light
5.36 g of d-lysergic acid are suspended in 125 ml of acetonitrile and the suspension cooled to
about -20 C in a bath of acetone cooled with dry ice. To the suspension is added a cold (-20 C)
solution of 8.82 g of trifluoroacetic anhydride
steinpilz sporen @ Sunday, November 23, 2014 1:54:26 PM